TRD Registry

Many people with depression have long, continuous episodes. When an episode lasts for 2 years or more, this is termed chronic depression. When several episodes of depression occur over time, the term recurrent depression may be used. Treatment-resistant depression (TRD) can be defined as chronic or recurrent depression that does not have an adequate response to several adequate antidepressant treatments.

TRD is not rare. About 1 in 6 Americans has depression over the course of a lifetime.1 As many as one third of people diagnosed with depression have TRD—long-term depression symptoms despite treatment.2 In addition, many people who do respond to antidepressant treatment still have some long-lasting symptoms or recurrences, or both.

Treatments may not work, or may stop working after a while. Or side effects may cause problems. This may be particularly true for chronic or recurrent depression.

Cyberonics is currently sponsoring a long-term, observational, multi-center patient outcome registry to collect data in patients with treatment-resistant depression. The purpose of this registry is to follow the clinical course and outcome for patients with TRD treated with and without adjunctive VNS Therapy.

Please note that because this is a post-approval registry, Cyberonics does not cover the cost of VNS Therapy implantation. However, the Case Management team at Cyberonics can assist the referring psychiatrist with the insurance prior authorization process.

To learn more about this registry and view the TRD Registry patient brochure in its entirety, please click here
There is also a brochure available for Health Care Professionals, please click here to view.

References: 1. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:593-602. 2. Fava M, Rush AJ, Trivedi MH, et al. Background and rationale for the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Psychiatr Clin North Am. 2003;26:457-494.